Swiss Scientists Develop New Gene Clock.

An international research team with Swiss participation has developed advanced “gene clocks” capable of measuring biological age and predicting lifespan in real time. The breakthrough study could transform future ageing research and health monitoring.

Scientists analysed more than 11,000 tissue samples collected from mice, rats, macaques, and humans. Researchers discovered that molecular ageing patterns inside the transcriptome remain remarkably similar across species and cell types.

The study reveals that ageing activates genes linked to inflammation, cell damage, and programmed cell death. At the same time, genes responsible for tissue repair, wound healing, and regeneration become less active as the body grows older.

Using this data, researchers created highly dynamic transcriptome clocks that can measure biological ageing more accurately. To validate the technology for humans, scientists tested the system using data from over 50,000 participants in the UK Biobank.

Experts say the new gene clocks perform similarly to modern epigenetic ageing clocks already used in scientific research. However, transcriptome clocks offer a major advantage because they respond quickly to changes happening inside cells in real time.

Researchers believe this technology could help scientists evaluate the effectiveness of anti-ageing treatments, diets, and medicines much faster than current methods. The discovery may open new opportunities in personalised healthcare and longevity research.

The study involved ETH Zurich researcher Adrian Molière and was led by Harvard Medical School scientist Vadim Gladyshev.